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| Cholesterol-Lowering
Medications |
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| Fibric Acid Derivatives |
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| Depletions |
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| Coenzyme
Q10 |
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A deficiency of the antioxidant coenzyme Q10 may be associated with long-term
conditions such as heart disease and high blood pressure. Symptoms of deficiency
include gingivitis, and weakened immune function. |
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| Vitamin
E |
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While deficiency of this nutrient is uncommon, it negatively affects muscle
tissue, red blood cells, nervous, and reproductive systems. Over the long-term,
depleted levels of this nutrient may also be associated with cancer, heart
disease, and altered immune function. |
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| Editorial Note |
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| Supporting Research |
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Aberg F, Appelkvist EL, Broijersen A, et al. Gemfibrozil-induced decrease in
serum ubiquinone and alpha- and gamma-tocopherol levels in men with combined
hyperlipidaemia. Eur J Clin Invest. 1998;28(3):235-242.
Ames BN. Micronutrient deficiencies: A major cause of DNA damage. Ann NY
Acad Sci. 2000;889:87-106.
Chan A, Reichmann H, Kogel A, et al. Metabolic changes in patients with
mitochondrial myopathies and effects of coenzyme Q10 therapy. J Neurol.
1998;245(10):681-685.
Covington T, ed. Nonprescription Drug Therapy Guiding Patient Self-Care. St
Louis, MO: Facts and Comparisons; 1999:467-545.
Folkers K, Morita M, McRee J Jr. The activities of coenzyme Q10 and vitamin
B6 for immune responses. Biochem Biophys Res Commun. 1993;
28(19391):88-92.
Kamikawa T, Kobayashi A, Yamashita T, et al. Effects of coenzyme Q10 on
exercise tolerance in chronic stable angina pectoris. Am J Cardiol.
1985;56(4):247-251.
Munkholm H, Hansen HH, Rasmussen K. Coenzyme Q10 treatment in serious heart
failure. Biofactors.1999;9(2-4):285-289.
Nakamura R, Littarru GP, Folkers R, et al. Study of CoQ10-enzymes in gingiva
from patients with periodontal disease and evidence for a deficiency of coenzyme
Q10. Proc Natl Acad SciUSA. 1974;71(4):1456-1460.
Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on
blood pressure and insulin resistance in hypertensive patients with coronary
heart disease. J Hum Hypertens. 1999;13(3):203-208.
Singh RB, Wander GS, Rastogi A, et al. Randomized, double-blind
placebo-controlled trial of coenzyme Q10 in patients with acute myocardial
infarction. Cardiovasc Drugs Ther. 1998;12(4):347-353.
Yoshida H, Ishikawa T, Ayaori M, et al. Beneficial effect of gemfibrozil on
the chemical composition and oxidative susceptibility of low density
lipoprotein: a randomized, double-blind, placebo-controlled study. Atherscl.
1998;139(1):179-187. |
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| Review Date:
October 2000 |
Reviewed By:
All depletions monographs have been reviewed by a
team of experts including
Derrick M. DeSilva, Jr., MD, Raritan Bay Medical Center, Perth Amboy, NJ;
Jacqueline A. Hart, MD, Department of Internal Medicine, Newton-Wellesley
Hospital, Harvard University and Senior Medical Editor, A.D.A.M., Inc., Boston,
MA; John Hinze, PharmD, NMD, Woodbine, IA; Ruth Marlin, MD, Medical Director and
Director of Medical Education, Preventive Medicine Research Institute,
Sausalito, CA; Brian T Sanderoff, PD, BS in Pharmacy, Clinical Assistant
Professor, University of Maryland School of Pharmacy; President, Your
Prescription for Health, Owings Mills, MD; Leonard Wisneski, MD, FACP, George
Washington University, Rockville, MD; Ira Zunin, MD, MPH, MBA, President and
Chairman, Hawaii State Consortium for Integrative Medicine, Honolulu,
HI.
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The publisher does not accept any responsibility for the
accuracy of the information or the consequences arising from the application,
use, or misuse of any of the information contained herein, including any injury
and/or damage to any person or property as a matter of product liability,
negligence, or otherwise. No warranty, expressed or implied, is made in regard
to the contents of this material. No claims or endorsements are made for any
drugs or compounds currently marketed or in investigative use. This material is
not intended as a guide to self-medication. The reader is advised to discuss the
information provided here with a doctor, pharmacist, nurse, or other authorized
healthcare practitioner and to check product information (including package
inserts) regarding dosage, precautions, warnings, interactions, and
contraindications before administering any drug, herb, or supplement discussed
herein. |
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