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| Cardiovascular
Medications |
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| Angiotensin-Converting Enzyme (ACE)
Inhibitors |
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| Depletions |
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| Zinc |
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Signs and symptoms of zinc deficiency include loss of appetite or sense of
taste, growth retardation, skin changes, and increased susceptibility to
infection. |

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| Editorial Note |
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| Supporting Research |
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Ames BN. Micronutrient deficiencies: A major cause of DNA damage. Ann NY
Acad Sci. 2000;889:87-106.
Falchuk KH. Disturbances in Trace Elements. In: Fauci A, Braunwald E,
Isselbacher KJ, et al, eds. Harrison's Principles of Internal Medicine.
14th ed. New York, NY: McGraw-Hill Companies Health Professional
Division; 1998:490-491.
Golik A, Modai D, Averbukh Z, et al. Zinc metabolism in patients treated with
captopril versus enalapril. Metab. 1990;39(7):665-667.
Golik A, Zaidenstein R, Dishi V, et al. Effects of captopril and enalapril on
zinc metabolism in hypertensive patients. J Am Coll Nutr.
1998;17(1):75-78.
Hambidge M. Human zinc deficiency. J Nutr. 2000;130(5S
Suppl):1344S-1349S.
Peczkowska M. [Influence of angiotensin I converting enzyme inhibitors on
selected parameters of zinc metabolism]. Pol Arch Med Wewn.
1996;96(1):32-38. |

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| Review Date:
October 2000 |
Reviewed By:
All depletions monographs have been reviewed by a
team of experts including
Derrick M. DeSilva, Jr., MD, Raritan Bay Medical Center, Perth Amboy, NJ;
Jacqueline A. Hart, MD, Department of Internal Medicine, Newton-Wellesley
Hospital, Harvard University and Senior Medical Editor, A.D.A.M., Inc., Boston,
MA; John Hinze, PharmD, NMD, Woodbine, IA; Ruth Marlin, MD, Medical Director and
Director of Medical Education, Preventive Medicine Research Institute,
Sausalito, CA; Brian T Sanderoff, PD, BS in Pharmacy, Clinical Assistant
Professor, University of Maryland School of Pharmacy; President, Your
Prescription for Health, Owings Mills, MD; Leonard Wisneski, MD, FACP, George
Washington University, Rockville, MD; Ira Zunin, MD, MPH, MBA, President and
Chairman, Hawaii State Consortium for Integrative Medicine, Honolulu,
HI.
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The publisher does not accept any responsibility for the
accuracy of the information or the consequences arising from the application,
use, or misuse of any of the information contained herein, including any injury
and/or damage to any person or property as a matter of product liability,
negligence, or otherwise. No warranty, expressed or implied, is made in regard
to the contents of this material. No claims or endorsements are made for any
drugs or compounds currently marketed or in investigative use. This material is
not intended as a guide to self-medication. The reader is advised to discuss the
information provided here with a doctor, pharmacist, nurse, or other authorized
healthcare practitioner and to check product information (including package
inserts) regarding dosage, precautions, warnings, interactions, and
contraindications before administering any drug, herb, or supplement discussed
herein. |
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